Assay Detail
Binding
CHEMBL815390
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Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Renal medulla |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent antagonists of vasopressin antidiuretic activity that lack the beta,beta-cyclopentamethylene-beta-mercaptopropionic acid substitution at position 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.23 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262423 | — | — | 1 | 8.41 |
| CHEMBL404820 | — | — | 1 | 8.28 |
| CHEMBL216606 | — | — | 1 | 8.19 |
| CHEMBL412392 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262423 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL404820 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL216606 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL412392 | — | Ki | = | 8.9 | nM | 8.05 |