Assay Detail
Binding
CHEMBL815425
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Inhibition of [Ca2+]/Mg2+ unactivated state of very late antigen 4 (VLA-4)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.30 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309823 | — | — | 1 | 9.57 |
| CHEMBL73986 | — | — | 1 | 9.51 |
| CHEMBL76295 | — | — | 1 | 8.74 |
| CHEMBL77924 | — | — | 1 | 8.44 |
| CHEMBL77586 | — | — | 1 | 7.68 |
| CHEMBL306739 | — | — | 1 | 7.66 |
| CHEMBL265778 | — | — | 1 | 7.48 |
| CHEMBL308346 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309823 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL73986 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL76295 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL77924 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL77586 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL306739 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL265778 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL308346 | — | IC50 | = | 52.0 | nM | 7.28 |