Assay Detail
Binding
CHEMBL815426
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Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.33 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309823 | — | — | 1 | 10.15 |
| CHEMBL73986 | — | — | 1 | 9.57 |
| CHEMBL77586 | — | — | 1 | 9.47 |
| CHEMBL76295 | — | — | 1 | 9.27 |
| CHEMBL306739 | — | — | 1 | 9.16 |
| CHEMBL77924 | — | — | 1 | 9.13 |
| CHEMBL308346 | — | — | 1 | 9.10 |
| CHEMBL265778 | — | — | 1 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309823 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL73986 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL77586 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL76295 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL306739 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL77924 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL308346 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL265778 | — | IC50 | = | 1.7 | nM | 8.77 |