Assay Detail
Binding
CHEMBL815468
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Inhibition of trypsin in human mast cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 4.64 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297220 | — | — | 1 | 5.36 |
| CHEMBL43938 | — | — | 1 | 5.33 |
| CHEMBL42037 | — | — | 1 | 4.78 |
| CHEMBL295007 | — | — | 1 | 4.68 |
| CHEMBL298256 | — | — | 1 | 4.60 |
| CHEMBL295450 | — | — | 1 | 4.43 |
| CHEMBL42899 | — | — | 1 | 4.41 |
| CHEMBL40491 | — | — | 1 | 4.33 |
| CHEMBL42898 | — | — | 1 | 4.28 |
| CHEMBL38054 | — | — | 1 | 4.20 |
| CHEMBL297408 | — | — | 1 | - |
| CHEMBL42364 | — | — | 1 | - |
| CHEMBL289918 | — | — | 1 | - |
| CHEMBL406192 | — | — | 1 | - |
| CHEMBL296733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297220 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL43938 | — | Ki | = | 4670.0 | nM | 5.33 |
| CHEMBL42037 | — | Ki | = | 16800.0 | nM | 4.78 |
| CHEMBL295007 | — | Ki | = | 21100.0 | nM | 4.68 |
| CHEMBL298256 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL295450 | — | Ki | = | 37400.0 | nM | 4.43 |
| CHEMBL42899 | — | Ki | = | 38800.0 | nM | 4.41 |
| CHEMBL40491 | — | Ki | = | 47200.0 | nM | 4.33 |
| CHEMBL42898 | — | Ki | = | 52100.0 | nM | 4.28 |
| CHEMBL38054 | — | Ki | = | 63100.0 | nM | 4.20 |
| CHEMBL297408 | — | Ki | = | 466000.0 | nM | - |
| CHEMBL42364 | — | Ki | = | 554000.0 | nM | - |
| CHEMBL289918 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL406192 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL296733 | — | Ki | = | 515000.0 | nM | - |