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Assay Detail

CHEMBL815469

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human trypsin (using Chromozym TH as the substrate)
ChEMBL ↗
116
Total Activities
116
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Trypsin (CHEMBL2095204) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1.
Supuran CT, Scozzafava A, Briganti F, Clare BW.
J Med Chem (2000) 43 : 1793 -1806
PubMed 10794696 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 116 5.87 6.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51971 — — 1 6.35
CHEMBL299617 — — 1 6.27
CHEMBL51173 — — 1 6.16
CHEMBL51292 — — 1 6.01
CHEMBL53694 — — 1 6.01
CHEMBL298869 — — 1 6.00
CHEMBL440114 — — 1 6.00
CHEMBL430592 — — 1 6.00
CHEMBL50574 — — 1 5.99
CHEMBL54299 — — 1 5.99
CHEMBL53801 — — 1 5.97
CHEMBL52968 — — 1 5.97
CHEMBL51102 — — 1 5.97
CHEMBL54241 — — 1 5.96
CHEMBL300708 — — 1 5.96
CHEMBL52915 — — 1 5.96
CHEMBL52109 — — 1 5.96
CHEMBL54261 — — 1 5.96
CHEMBL53755 — — 1 5.96
CHEMBL52803 — — 1 5.94
CHEMBL300407 — — 1 5.94
CHEMBL50522 — — 1 5.93
CHEMBL50467 — — 1 5.92
CHEMBL51392 — — 1 5.92
CHEMBL53533 — — 1 5.92
CHEMBL50537 — — 1 5.92
CHEMBL299607 — — 1 5.92
CHEMBL301082 — — 1 5.92
CHEMBL52161 — — 1 5.91
CHEMBL50144 — — 1 5.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51971 — Ki = 450.0 nM 6.35
CHEMBL299617 — Ki = 540.0 nM 6.27
CHEMBL51173 — Ki = 690.0 nM 6.16
CHEMBL53694 — Ki = 975.0 nM 6.01
CHEMBL51292 — Ki = 980.0 nM 6.01
CHEMBL298869 — Ki = 990.0 nM 6.00
CHEMBL440114 — Ki = 1010.0 nM 6.00
CHEMBL430592 — Ki = 990.0 nM 6.00
CHEMBL54299 — Ki = 1025.0 nM 5.99
CHEMBL50574 — Ki = 1025.0 nM 5.99
CHEMBL51102 — Ki = 1080.0 nM 5.97
CHEMBL52968 — Ki = 1075.0 nM 5.97
CHEMBL53801 — Ki = 1070.0 nM 5.97
CHEMBL53755 — Ki = 1090.0 nM 5.96
CHEMBL52915 — Ki = 1100.0 nM 5.96
CHEMBL300708 — Ki = 1100.0 nM 5.96
CHEMBL52109 — Ki = 1100.0 nM 5.96
CHEMBL54241 — Ki = 1100.0 nM 5.96
CHEMBL54261 — Ki = 1100.0 nM 5.96
CHEMBL52803 — Ki = 1145.0 nM 5.94
CHEMBL300407 — Ki = 1150.0 nM 5.94
CHEMBL50522 — Ki = 1170.0 nM 5.93
CHEMBL299607 — Ki = 1200.0 nM 5.92
CHEMBL301082 — Ki = 1215.0 nM 5.92
CHEMBL50537 — Ki = 1200.0 nM 5.92
CHEMBL51392 — Ki = 1200.0 nM 5.92
CHEMBL50467 — Ki = 1200.0 nM 5.92
CHEMBL53533 — Ki = 1200.0 nM 5.92
CHEMBL52161 — Ki = 1235.0 nM 5.91
CHEMBL50144 — Ki = 1230.0 nM 5.91
CHEMBL53358 — Ki = 1235.0 nM 5.91
CHEMBL298996 — Ki = 1245.0 nM 5.91
CHEMBL50253 — Ki = 1235.0 nM 5.91
CHEMBL52846 — Ki = 1230.0 nM 5.91
CHEMBL50155 — Ki = 1235.0 nM 5.91
CHEMBL51635 — Ki = 1250.0 nM 5.90
CHEMBL299652 — Ki = 1250.0 nM 5.90
CHEMBL50022 — Ki = 1275.0 nM 5.89
CHEMBL53960 — Ki = 1300.0 nM 5.89
CHEMBL50449 — Ki = 1300.0 nM 5.89
CHEMBL301987 — Ki = 1285.0 nM 5.89
CHEMBL296177 — Ki = 1285.0 nM 5.89
CHEMBL50889 — Ki = 1275.0 nM 5.89
CHEMBL301750 — Ki = 1300.0 nM 5.89
CHEMBL300630 — Ki = 1315.0 nM 5.88
CHEMBL53464 — Ki = 1320.0 nM 5.88
CHEMBL51997 — Ki = 1325.0 nM 5.88
CHEMBL51103 — Ki = 1320.0 nM 5.88
CHEMBL51261 — Ki = 1320.0 nM 5.88
CHEMBL51458 — Ki = 1335.0 nM 5.88