Assay Detail
Binding
CHEMBL815507
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Compound was evaluated for the inhibition of human Thymidylate Synthase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.95 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 8.00 |
| CHEMBL422395 | — | — | 1 | 8.00 |
| CHEMBL330484 | — | — | 1 | 6.37 |
| CHEMBL92234 | — | — | 1 | 6.13 |
| CHEMBL419876 | — | — | 1 | 5.85 |
| CHEMBL90795 | — | — | 1 | 4.62 |
| CHEMBL329619 | — | — | 1 | 4.51 |
| CHEMBL92589 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL422395 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL330484 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL92234 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL419876 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL90795 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL329619 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL92589 | — | IC50 | = | 83000.0 | nM | 4.08 |