Assay Detail
Binding
CHEMBL815565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant of thymidylate synthase was determined in human AML cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | AML |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Folate analogues as inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.18 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389051 | — | — | 1 | 8.15 |
| CHEMBL158990 | METHOPTERINE | — | 1 | 6.00 |
| CHEMBL1622 | FOLIC ACID | 4.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389051 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL158990 | METHOPTERINE | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1622 | FOLIC ACID | Ki | = | 40000.0 | nM | 4.40 |