Assay Detail
Binding
CHEMBL815566
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Inhibitory effect against recombinant human thymidylate synthase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.62 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55263 | — | — | 1 | 8.40 |
| CHEMBL56523 | — | — | 1 | 8.22 |
| CHEMBL57420 | — | — | 1 | 8.00 |
| CHEMBL59203 | — | — | 1 | 7.85 |
| CHEMBL434980 | — | — | 1 | 7.85 |
| CHEMBL9440 | METESIND | 2.0 | 1 | 7.82 |
| CHEMBL293823 | — | — | 1 | 7.82 |
| CHEMBL55884 | — | — | 1 | 7.77 |
| CHEMBL294871 | — | — | 1 | 7.75 |
| CHEMBL56611 | — | — | 1 | 7.60 |
| CHEMBL293810 | — | — | 1 | 7.52 |
| CHEMBL301218 | — | — | 1 | 7.35 |
| CHEMBL56637 | — | — | 1 | 7.28 |
| CHEMBL55361 | — | — | 1 | 6.57 |
| CHEMBL417763 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55263 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL56523 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL57420 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL59203 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL434980 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL9440 | METESIND | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL293823 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL55884 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL294871 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL56611 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL293810 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL301218 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL56637 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL55361 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL417763 | — | Ki | = | 310.0 | nM | 6.51 |