Assay Detail
Functional
CHEMBL815688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine tubulin polymerization
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.18 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15778 | — | — | 1 | 6.50 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.34 |
| CHEMBL342203 | — | — | 1 | 5.96 |
| CHEMBL142145 | — | — | 1 | 5.82 |
| CHEMBL138976 | — | — | 1 | 5.46 |
| CHEMBL141894 | — | — | 1 | 5.36 |
| CHEMBL140434 | — | — | 1 | 5.25 |
| CHEMBL18869 | — | — | 1 | 5.17 |
| CHEMBL278647 | — | — | 1 | 5.04 |
| CHEMBL142092 | — | — | 1 | 5.03 |
| CHEMBL433686 | — | — | 1 | 5.02 |
| CHEMBL140762 | — | — | 1 | 5.00 |
| CHEMBL137821 | — | — | 1 | 4.96 |
| CHEMBL137987 | — | — | 1 | 4.96 |
| CHEMBL336718 | — | — | 1 | 4.92 |
| CHEMBL138456 | — | — | 1 | 4.92 |
| CHEMBL18670 | — | — | 1 | 4.92 |
| CHEMBL436410 | — | — | 1 | 4.92 |
| CHEMBL136390 | — | — | 1 | 4.92 |
| CHEMBL343350 | — | — | 1 | 4.85 |
| CHEMBL137922 | — | — | 1 | 4.82 |
| CHEMBL342882 | — | — | 1 | 4.82 |
| CHEMBL342675 | — | — | 1 | 4.77 |
| CHEMBL137859 | — | — | 1 | 4.50 |
| CHEMBL141110 | — | — | 1 | - |
| CHEMBL414617 | — | — | 1 | - |
| CHEMBL138006 | — | — | 1 | - |
| CHEMBL342391 | — | — | 1 | - |
| CHEMBL138007 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15778 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL61 | PODOFILOX | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL342203 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL142145 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL138976 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL141894 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL140434 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL18869 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL278647 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL142092 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL433686 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL140762 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL137821 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL137987 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL336718 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL138456 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL18670 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL436410 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL136390 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL343350 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL137922 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL342882 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL342675 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL137859 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL141110 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL414617 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL138006 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL342391 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL138007 | — | IC50 | > | 40000.0 | nM | - |