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Assay Detail

CHEMBL815690

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of bovine electrophoretically homogeneous tubulin polymerization.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Bos taurus
Confidence 7 — Homologous single protein target
Curated By Expert

Target

Tubulin (CHEMBL2111464)
Type PROTEIN COMPLEX
Organism Bos taurus

Publication

Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.
Cushman M, He HM, Lin CM, Hamel E.
J Med Chem (1993) 36 : 2817 -2821
PubMed 8410995 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.21 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL47426 1 5.70
CHEMBL97291 1 5.52
CHEMBL97301 1 5.46
CHEMBL86960 1 5.34
CHEMBL95144 1 5.22
CHEMBL96202 1 5.14
CHEMBL98235 1 5.05
CHEMBL319751 1 4.96
CHEMBL320911 1 4.92
CHEMBL96430 1 4.80
CHEMBL540951 1 -
CHEMBL93929 1 -
CHEMBL96518 1 -
CHEMBL96692 1 -
CHEMBL94594 1 -
CHEMBL96409 1 -
CHEMBL96123 1 -
CHEMBL96393 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL47426 IC50 = 2000.0 nM 5.70
CHEMBL97291 IC50 = 3000.0 nM 5.52
CHEMBL97301 IC50 = 3500.0 nM 5.46
CHEMBL86960 IC50 = 4600.0 nM 5.34
CHEMBL95144 IC50 = 6000.0 nM 5.22
CHEMBL96202 IC50 = 7200.0 nM 5.14
CHEMBL98235 IC50 = 8900.0 nM 5.05
CHEMBL319751 IC50 = 11000.0 nM 4.96
CHEMBL320911 IC50 = 12000.0 nM 4.92
CHEMBL96430 IC50 = 16000.0 nM 4.80
CHEMBL540951 IC50 > 40000.0 nM -
CHEMBL93929 IC50 > 40000.0 nM -
CHEMBL96518 IC50 > 40000.0 nM -
CHEMBL96692 IC50 > 40000.0 nM -
CHEMBL94594 IC50 > 40000.0 nM -
CHEMBL96409 IC50 > 40000.0 nM -
CHEMBL96123 IC50 > 40000.0 nM -
CHEMBL96393 IC50 > 40000.0 nM -