Assay Detail
Binding
CHEMBL815712
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Binding affinity towards tissue type plasminogen activator
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.53 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421214 | — | — | 1 | 6.89 |
| CHEMBL319047 | — | — | 1 | 6.75 |
| CHEMBL104166 | — | — | 1 | 6.17 |
| CHEMBL104505 | — | — | 1 | 6.09 |
| CHEMBL105395 | — | — | 1 | 6.06 |
| CHEMBL320233 | — | — | 1 | 5.80 |
| CHEMBL104211 | — | — | 1 | 5.48 |
| CHEMBL320817 | — | — | 1 | 5.13 |
| CHEMBL321319 | — | — | 1 | 5.08 |
| CHEMBL104904 | — | — | 1 | 4.75 |
| CHEMBL103043 | — | — | 1 | 4.62 |
| CHEMBL319264 | — | — | 1 | 4.57 |
| CHEMBL104937 | — | — | 1 | 4.50 |
| CHEMBL105171 | — | — | 1 | - |
| CHEMBL321944 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421214 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL319047 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL104166 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL104505 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL105395 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL320233 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL104211 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL320817 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL321319 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL104904 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL103043 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL319264 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL104937 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL105171 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL321944 | — | Ki | > | 100000.0 | nM | - |