Assay Detail
Binding
CHEMBL815722
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Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.70 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319035 | — | — | 1 | 4.70 |
| CHEMBL107627 | — | — | 1 | - |
| CHEMBL107911 | — | — | 1 | - |
| CHEMBL107282 | — | — | 1 | - |
| CHEMBL322901 | — | — | 1 | - |
| CHEMBL107743 | — | — | 1 | - |
| CHEMBL322165 | — | — | 1 | - |
| CHEMBL107392 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319035 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL107627 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL107911 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL107282 | — | Ki | = | 180000.0 | nM | - |
| CHEMBL322901 | — | Ki | = | 410000.0 | nM | - |
| CHEMBL107743 | — | Ki | = | 470000.0 | nM | - |
| CHEMBL322165 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL107392 | — | Ki | = | 190000.0 | nM | - |