Assay Detail
Functional
CHEMBL815728
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Compound tested for inhibition of concanavalin A stimulated thymocytes in Tolypocladium inflatum gams
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Tolypocladium inflatum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, conformation, and immunosuppressive activity of a conformationally restricted cyclosporine lactam analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.63 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.30 |
| CHEMBL407690 | — | — | 1 | 8.22 |
| CHEMBL263816 | — | — | 1 | 7.00 |
| CHEMBL442476 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL407690 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL263816 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL442476 | — | IC50 | = | 100.0 | nM | 7.00 |