Assay Detail
Functional
CHEMBL815858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in U937 (human leukemia)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.31 | 10.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30424 | — | — | 1 | 10.33 |
| CHEMBL31400 | ELINAFIDE | 2.0 | 1 | 9.47 |
| CHEMBL31879 | — | — | 1 | 9.28 |
| CHEMBL30232 | — | — | 1 | 8.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30424 | — | IC50 | = | 0.047 | nM | 10.33 |
| CHEMBL31400 | ELINAFIDE | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL31879 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL30232 | — | IC50 | = | 6.9 | nM | 8.16 |