Assay Detail
Functional
CHEMBL815864
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Ability to elevate intracellular levels of cAMP in human U937 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.79 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162663 | — | — | 1 | 7.66 |
| CHEMBL352153 | — | — | 1 | 7.34 |
| CHEMBL166320 | — | — | 1 | 7.31 |
| CHEMBL165158 | — | — | 1 | 7.09 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.91 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162663 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL352153 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL166320 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL165158 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 3630.0 | nM | 5.44 |