Assay Detail
Functional
CHEMBL815865
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In vitro blocking of extracellular calcium mobilization in human U937 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.17 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96224 | — | — | 1 | 9.52 |
| CHEMBL96206 | — | — | 1 | 9.15 |
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 9.00 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96224 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL96206 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL21333 | PRANLUKAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 1.0 | nM | 9.00 |