Assay Detail
Functional
CHEMBL815870
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Evaluated for inhibition of tubulin polymerization.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.45 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627442 | — | — | 1 | 5.89 |
| CHEMBL1627875 | — | — | 1 | 5.82 |
| CHEMBL1627475 | — | — | 1 | 5.54 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | 2.0 | 1 | 5.51 |
| CHEMBL1627880 | — | — | 1 | 5.39 |
| CHEMBL1627463 | — | — | 1 | 5.37 |
| CHEMBL77320 | — | — | 1 | 5.36 |
| CHEMBL1627461 | — | — | 1 | 5.32 |
| CHEMBL1627882 | — | — | 1 | 5.23 |
| CHEMBL1627888 | — | — | 1 | 5.06 |
| CHEMBL1627467 | — | — | 1 | - |
| CHEMBL1627462 | — | — | 1 | - |
| CHEMBL1627891 | — | — | 1 | - |
| CHEMBL1627468 | — | — | 1 | - |
| CHEMBL1627466 | — | — | 1 | - |
| CHEMBL1627472 | — | — | 1 | - |
| CHEMBL1627474 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627442 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1627875 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1627475 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1627880 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1627463 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL77320 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1627461 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1627882 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1627888 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1627467 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1627462 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1627891 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1627468 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1627466 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1627472 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1627474 | — | IC50 | > | 40000.0 | nM | - |