Assay Detail
Binding
CHEMBL815874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerization (ITP).
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.92 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.34 |
| CHEMBL15778 | — | — | 1 | 6.31 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.28 |
| CHEMBL273311 | — | — | 1 | 6.25 |
| CHEMBL15997 | — | — | 1 | 6.18 |
| CHEMBL16227 | — | — | 1 | 6.16 |
| CHEMBL279142 | — | — | 1 | 6.13 |
| CHEMBL16058 | — | — | 1 | 6.12 |
| CHEMBL16221 | — | — | 1 | 6.12 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.10 |
| CHEMBL276541 | — | — | 1 | 6.10 |
| CHEMBL16430 | — | — | 1 | 6.09 |
| CHEMBL16092 | — | — | 1 | 5.96 |
| CHEMBL16065 | — | — | 1 | 5.92 |
| CHEMBL276340 | — | — | 1 | 5.82 |
| CHEMBL277796 | — | — | 1 | 5.70 |
| CHEMBL16116 | — | — | 1 | 5.64 |
| CHEMBL440091 | Aza-flavanone | — | 1 | 5.57 |
| CHEMBL274468 | — | — | 1 | 5.48 |
| CHEMBL16612 | — | — | 1 | 5.14 |
| CHEMBL16611 | — | — | 1 | 4.92 |
| CHEMBL16198 | — | — | 1 | - |
| CHEMBL278746 | — | — | 1 | - |
| CHEMBL278893 | — | — | 1 | - |
| CHEMBL273550 | — | — | 1 | - |
| CHEMBL15983 | — | — | 1 | - |
| CHEMBL273803 | — | — | 1 | - |
| CHEMBL16128 | — | — | 1 | - |
| CHEMBL16151 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL15778 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL273311 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL15997 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL16227 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL279142 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL16058 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL16221 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL107 | COLCHICINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL276541 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL16430 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL16092 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL16065 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL276340 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL277796 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL16116 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL440091 | Aza-flavanone | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL274468 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL16612 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL16611 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL16198 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL278746 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL278893 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL273550 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL15983 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL273803 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL16128 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL16151 | — | IC50 | > | 40000.0 | nM | - |