Assay Detail
Functional
CHEMBL815970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Arbitary maximal response for cAMP elevation from baseline level was evaluated in Human U-937 cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.41 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74597 | — | — | 1 | 9.00 |
| CHEMBL308784 | — | — | 1 | 7.77 |
| CHEMBL305806 | — | — | 1 | 7.44 |
| CHEMBL310509 | — | — | 1 | 7.44 |
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 7.40 |
| CHEMBL309803 | — | — | 1 | 7.39 |
| CHEMBL307286 | — | — | 1 | 7.16 |
| CHEMBL32442 | CDP840 | — | 1 | 6.54 |
| CHEMBL307678 | — | — | 1 | 6.48 |
| CHEMBL75819 | — | — | 1 | 6.48 |
| CHEMBL308180 | — | — | 1 | 6.30 |
| CHEMBL75247 | — | — | 1 | 6.28 |
| CHEMBL75722 | — | — | 1 | 6.11 |
| CHEMBL73894 | — | — | 1 | 6.06 |
| CHEMBL76066 | — | — | 1 | 6.01 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.91 |
| CHEMBL72688 | — | — | 1 | 5.49 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 5.44 |
| CHEMBL76065 | — | — | 1 | 5.28 |
| CHEMBL74774 | — | — | 1 | 5.20 |
| CHEMBL306335 | — | — | 1 | 4.96 |
| CHEMBL307511 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74597 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL308784 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL305806 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL310509 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL42126 | PICLAMILAST | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL309803 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL307286 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL32442 | CDP840 | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL307678 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL75819 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL308180 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL75247 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL75722 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL73894 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL76066 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL63 | ROLIPRAM | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL72688 | — | EC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL511115 | CILOMILAST | EC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL76065 | — | EC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL74774 | — | EC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL306335 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL307511 | — | EC50 | = | 13000.0 | nM | 4.89 |