Assay Detail
Functional
CHEMBL815972
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Compound was tested for anti-proliferative activity in U-937 human leukemia cell line
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.29 | 4.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 4.48 |
| CHEMBL140525 | — | — | 1 | 4.40 |
| CHEMBL336935 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL140525 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL336935 | — | EC50 | = | 100000.0 | nM | 4.00 |