Assay Detail
Functional
CHEMBL816023
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Ability to inhibit release of interleukin-6 from U2OS cell lines transfected with estrogen receptor alpha
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Lead identification of a potent benzopyranone selective estrogen receptor modulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.87 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439967 | — | — | 1 | 9.42 |
| CHEMBL113712 | — | — | 1 | 8.82 |
| CHEMBL2137046 | — | — | 1 | 8.72 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.51 |
| CHEMBL115000 | — | — | 1 | 8.49 |
| CHEMBL326146 | — | — | 1 | 8.36 |
| CHEMBL115303 | — | — | 1 | 8.30 |
| CHEMBL115489 | — | — | 1 | 7.96 |
| CHEMBL262042 | — | — | 1 | 7.92 |
| CHEMBL115060 | — | — | 1 | 7.16 |
| CHEMBL325889 | — | — | 1 | 6.94 |
| CHEMBL421892 | — | — | 1 | 6.84 |
| CHEMBL115194 | — | — | 1 | 6.45 |
| CHEMBL117263 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439967 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL113712 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2137046 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL115000 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL326146 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL115303 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL115489 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL262042 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL115060 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL325889 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL421892 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL115194 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL117263 | — | IC50 | = | 505.0 | nM | 6.30 |