Assay Detail
Binding
CHEMBL816092
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Binding affinity towards HSV-1 thymidine kinase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Thymidine kinase (CHEMBL1820) ↗| Type | SINGLE PROTEIN |
| Organism | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
Publication
Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.21 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 6.52 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 1 | 6.00 |
| CHEMBL1791148 | — | — | 1 | 5.82 |
| CHEMBL1791152 | — | — | 1 | 5.64 |
| CHEMBL2367577 | — | — | 1 | 5.64 |
| CHEMBL1791149 | — | — | 1 | 5.62 |
| CHEMBL2367583 | — | — | 1 | 5.54 |
| CHEMBL3143229 | — | — | 1 | 5.51 |
| CHEMBL1231486 | — | — | 1 | 5.46 |
| CHEMBL1791157 | — | — | 1 | 5.40 |
| CHEMBL2367579 | — | — | 1 | 4.55 |
| CHEMBL2368961 | — | — | 1 | 4.47 |
| CHEMBL1791154 | — | — | 1 | 4.44 |
| CHEMBL2367580 | — | — | 1 | 4.29 |
| CHEMBL3143226 | — | — | 1 | 4.21 |
| CHEMBL3143224 | — | — | 1 | 4.21 |
| CHEMBL3143223 | — | — | 1 | - |
| CHEMBL3143225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL52609 | DOXRIBTIMINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1791148 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1791152 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2367577 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1791149 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2367583 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3143229 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1231486 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1791157 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2367579 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2368961 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1791154 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2367580 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3143226 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL3143224 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL3143223 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL3143225 | — | IC50 | = | 102000.0 | nM | - |