Assay Detail
Functional
CHEMBL816102
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Inhibitory activity against growth of WI-L2 murine leukemic cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | WI-L2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.11 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35921 | — | — | 1 | 6.80 |
| CHEMBL32439 | — | — | 1 | 6.75 |
| CHEMBL287532 | — | — | 1 | 6.07 |
| CHEMBL280864 | — | — | 1 | 5.58 |
| CHEMBL32691 | — | — | 1 | 5.37 |
| CHEMBL35231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35921 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL32439 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL287532 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL280864 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL32691 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL35231 | — | IC50 | - | nM | - |