Assay Detail
Functional
CHEMBL816182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.53 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44207 | — | — | 1 | 8.77 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.09 |
| CHEMBL43809 | — | — | 1 | 7.92 |
| CHEMBL40865 | — | — | 1 | 7.77 |
| CHEMBL42100 | — | — | 1 | 7.77 |
| CHEMBL40716 | — | — | 1 | 7.75 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.28 |
| CHEMBL288699 | — | — | 1 | 7.05 |
| CHEMBL289120 | — | — | 1 | 6.96 |
| CHEMBL40924 | — | — | 1 | 6.77 |
| CHEMBL288217 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44207 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL43809 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL40865 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL42100 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL40716 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL288699 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL289120 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL40924 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL288217 | — | IC50 | = | 180.0 | nM | 6.75 |