Assay Detail
Functional
CHEMBL816201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against human colon carcinoma sensitive WiDr cell line.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.22 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.09 |
| CHEMBL149293 | — | — | 1 | 8.05 |
| CHEMBL343913 | — | — | 1 | 8.02 |
| CHEMBL147372 | — | — | 1 | 7.96 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.89 |
| CHEMBL148281 | — | — | 1 | 7.77 |
| CHEMBL146785 | — | — | 1 | 7.77 |
| CHEMBL146516 | — | — | 1 | 7.77 |
| CHEMBL144014 | — | — | 1 | 7.77 |
| CHEMBL344310 | — | — | 1 | 7.70 |
| CHEMBL422137 | — | — | 1 | 7.40 |
| CHEMBL149184 | — | — | 1 | 7.40 |
| CHEMBL356797 | — | — | 1 | 7.29 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.28 |
| CHEMBL439812 | — | — | 1 | 7.19 |
| CHEMBL439632 | — | — | 1 | 7.00 |
| CHEMBL148344 | — | — | 1 | 7.00 |
| CHEMBL356785 | — | — | 1 | 6.92 |
| CHEMBL146559 | — | — | 1 | 6.89 |
| CHEMBL147428 | — | — | 1 | 6.75 |
| CHEMBL148229 | — | — | 1 | 6.41 |
| CHEMBL343852 | — | — | 1 | 6.40 |
| CHEMBL358993 | — | — | 1 | 6.18 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.96 |
| CHEMBL422843 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL149293 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL343913 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL147372 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL148281 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL146785 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL146516 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL144014 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL344310 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL422137 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL149184 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL356797 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL439812 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL439632 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL148344 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL356785 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL146559 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL147428 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL148229 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL343852 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL358993 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL422843 | — | IC50 | = | 2220.0 | nM | 5.65 |