Assay Detail
Functional
CHEMBL816202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against human colon carcinoma multi drug resistant (MDR)-WiDr cell line.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.78 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146785 | — | — | 1 | 7.89 |
| CHEMBL147372 | — | — | 1 | 7.80 |
| CHEMBL144014 | — | — | 1 | 7.70 |
| CHEMBL149293 | — | — | 1 | 7.52 |
| CHEMBL422137 | — | — | 1 | 7.21 |
| CHEMBL356797 | — | — | 1 | 7.19 |
| CHEMBL343913 | — | — | 1 | 7.13 |
| CHEMBL148281 | — | — | 1 | 7.07 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.03 |
| CHEMBL344310 | — | — | 1 | 6.96 |
| CHEMBL345020 | — | — | 1 | 6.92 |
| CHEMBL147576 | — | — | 1 | 6.92 |
| CHEMBL356785 | — | — | 1 | 6.92 |
| CHEMBL439812 | — | — | 1 | 6.89 |
| CHEMBL149184 | — | — | 1 | 6.89 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.89 |
| CHEMBL148344 | — | — | 1 | 6.85 |
| CHEMBL146516 | — | — | 1 | 6.62 |
| CHEMBL439632 | — | — | 1 | 6.57 |
| CHEMBL147428 | — | — | 1 | 6.50 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 6.31 |
| CHEMBL343852 | — | — | 1 | 6.17 |
| CHEMBL358993 | — | — | 1 | 6.05 |
| CHEMBL146559 | — | — | 1 | 6.05 |
| CHEMBL148229 | — | — | 1 | 6.00 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.66 |
| CHEMBL422843 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146785 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL147372 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL144014 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL149293 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL422137 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL356797 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL343913 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL148281 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL344310 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL345020 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL147576 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL356785 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL439812 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL149184 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL148344 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL146516 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL439632 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL147428 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL343852 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL358993 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL146559 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL148229 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL422843 | — | IC50 | = | 4700.0 | nM | 5.33 |