Assay Detail
Binding
CHEMBL816229
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Displacement of vitronectin from human integrin alphaV-beta5
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.64 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109930 | — | — | 1 | 10.00 |
| CHEMBL327102 | — | — | 1 | 9.70 |
| CHEMBL109703 | — | — | 1 | 9.52 |
| CHEMBL113063 | — | — | 1 | 9.30 |
| CHEMBL113853 | — | — | 1 | 9.10 |
| CHEMBL111401 | — | — | 1 | 9.05 |
| CHEMBL110039 | — | — | 1 | 7.70 |
| CHEMBL109817 | — | — | 1 | 7.66 |
| CHEMBL111986 | — | — | 1 | 7.40 |
| CHEMBL421890 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109930 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL327102 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL109703 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL113063 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL113853 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL111401 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL110039 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL109817 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL111986 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL421890 | — | IC50 | = | 119.0 | nM | 6.92 |