Assay Detail
Binding
CHEMBL816398
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Inhibition of c-Jun N-terminal kinase 2-alpha 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.00 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 6.54 |
| CHEMBL305178 | — | — | 1 | 6.17 |
| CHEMBL307980 | — | — | 1 | 6.13 |
| CHEMBL303144 | — | — | 1 | 5.93 |
| CHEMBL308939 | — | — | 1 | 5.76 |
| CHEMBL424418 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL305178 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL307980 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL303144 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL308939 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL424418 | — | IC50 | = | 3300.0 | nM | 5.48 |