Assay Detail
Binding
CHEMBL816426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Taq DNA polymerase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Thermus aquaticus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.06 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346068 | — | — | 1 | 7.22 |
| CHEMBL155344 | — | — | 1 | 6.17 |
| CHEMBL350251 | — | — | 1 | 5.62 |
| CHEMBL154276 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346068 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL155344 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL350251 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL154276 | — | IC50 | = | 5700.0 | nM | 5.24 |