Assay Detail
Binding
CHEMBL816487
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Inhibition of type 1 steroid-5-alpha-reductase
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.14 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421627 | — | — | 1 | 9.22 |
| CHEMBL25448 | — | — | 1 | 9.05 |
| CHEMBL126686 | — | — | 1 | 8.80 |
| CHEMBL340027 | — | — | 1 | 8.77 |
| CHEMBL128023 | — | — | 1 | 8.70 |
| CHEMBL338376 | — | — | 1 | 8.60 |
| CHEMBL340715 | — | — | 1 | 8.59 |
| CHEMBL340181 | — | — | 1 | 8.59 |
| CHEMBL340684 | — | — | 1 | 8.57 |
| CHEMBL340305 | — | — | 1 | 8.48 |
| CHEMBL125855 | — | — | 1 | 8.37 |
| CHEMBL338207 | — | — | 1 | 8.30 |
| CHEMBL127702 | — | — | 1 | 8.24 |
| CHEMBL125209 | — | — | 1 | 8.08 |
| CHEMBL332781 | — | — | 1 | 8.07 |
| CHEMBL24955 | BEXLOSTERIDE | 2.0 | 1 | 8.07 |
| CHEMBL414427 | — | — | 1 | 8.02 |
| CHEMBL125260 | — | — | 1 | 8.02 |
| CHEMBL338707 | — | — | 1 | 7.72 |
| CHEMBL126968 | — | — | 1 | 7.70 |
| CHEMBL127760 | — | — | 1 | 7.38 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 7.28 |
| CHEMBL124750 | — | — | 1 | 7.24 |
| CHEMBL339912 | — | — | 1 | 6.87 |
| CHEMBL323996 | — | — | 1 | 6.73 |
| CHEMBL124803 | — | — | 1 | - |
| CHEMBL414428 | — | — | 1 | - |
| CHEMBL125579 | — | — | 1 | - |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421627 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL25448 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL126686 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL340027 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL128023 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL338376 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL340715 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL340181 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL340684 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL340305 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL125855 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL338207 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL127702 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL125209 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL332781 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL24955 | BEXLOSTERIDE | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL414427 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL125260 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL338707 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL126968 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL127760 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL710 | FINASTERIDE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL124750 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL339912 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL323996 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL124803 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL414428 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL125579 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL138225 | EPRISTERIDE | IC50 | > | 1000.0 | nM | - |