Assay Detail
Binding
CHEMBL816494
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In vitro inhibitory activity against human type 1 5-alpha reductase
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 70 | 6.79 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159458 | — | — | 1 | 9.40 |
| CHEMBL307745 | — | — | 1 | 9.00 |
| CHEMBL306289 | — | — | 1 | 8.96 |
| CHEMBL80160 | — | — | 1 | 8.51 |
| CHEMBL311045 | — | — | 1 | 8.49 |
| CHEMBL77290 | — | — | 1 | 8.44 |
| CHEMBL430617 | — | — | 1 | 8.40 |
| CHEMBL305855 | — | — | 1 | 8.35 |
| CHEMBL2298601 | — | — | 1 | 8.30 |
| CHEMBL307398 | — | — | 1 | 8.21 |
| CHEMBL306554 | — | — | 1 | 8.19 |
| CHEMBL3085538 | — | — | 1 | 8.16 |
| CHEMBL308258 | — | — | 1 | 8.09 |
| CHEMBL76260 | — | — | 1 | 8.07 |
| CHEMBL310711 | — | — | 1 | 8.07 |
| CHEMBL420020 | — | — | 1 | 8.05 |
| CHEMBL77024 | — | — | 1 | 7.96 |
| CHEMBL311577 | — | — | 1 | 7.92 |
| CHEMBL78275 | — | — | 1 | 7.92 |
| CHEMBL312531 | — | — | 1 | 7.85 |
| CHEMBL76637 | — | — | 1 | 7.82 |
| CHEMBL306722 | — | — | 1 | 7.70 |
| CHEMBL77328 | — | — | 1 | 7.70 |
| CHEMBL412425 | — | — | 1 | 7.70 |
| CHEMBL24088 | — | — | 1 | 7.52 |
| CHEMBL78064 | — | — | 1 | 7.42 |
| CHEMBL306781 | — | — | 1 | 7.41 |
| CHEMBL77765 | — | — | 1 | 7.40 |
| CHEMBL3706581 | — | — | 1 | 7.32 |
| CHEMBL432729 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159458 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL307745 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL306289 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL80160 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL311045 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL77290 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL430617 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL305855 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL2298601 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL307398 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL306554 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL3085538 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL308258 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL310711 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL76260 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL420020 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL77024 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL311577 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL78275 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL312531 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL76637 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL306722 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL77328 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL412425 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL24088 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL78064 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL306781 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL77765 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3706581 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL432729 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL75320 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3706584 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL77144 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL77129 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL312143 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL307181 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL297524 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL76892 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3706585 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL308107 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL77124 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL309585 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL73816 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL76803 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL76648 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL76192 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL78161 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL308532 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL309261 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL306507 | — | Ki | = | 1400.0 | nM | 5.85 |