Assay Detail
Binding
CHEMBL816539
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Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tripeptidyl-peptidase II (TPP II) inhibitory activity of (S)-2,3-dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a systematic SAR evaluation. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.44 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341545 | — | — | 1 | 8.40 |
| CHEMBL141228 | — | — | 1 | 8.40 |
| CHEMBL344682 | — | — | 1 | 8.30 |
| CHEMBL140029 | — | — | 1 | 8.22 |
| CHEMBL345086 | — | — | 1 | 7.96 |
| CHEMBL140875 | — | — | 1 | 7.70 |
| CHEMBL337314 | — | — | 1 | 7.64 |
| CHEMBL337540 | — | — | 1 | 7.44 |
| CHEMBL138968 | — | — | 1 | 7.34 |
| CHEMBL138058 | — | — | 1 | 7.16 |
| CHEMBL344851 | — | — | 1 | 6.71 |
| CHEMBL138313 | — | — | 1 | 5.85 |
| CHEMBL138518 | — | — | 1 | 5.64 |
| CHEMBL137926 | — | — | 1 | - |
| CHEMBL341589 | — | — | 1 | - |
| CHEMBL138051 | — | — | 1 | - |
| CHEMBL443220 | — | — | 1 | - |
| CHEMBL139137 | — | — | 1 | - |
| CHEMBL138160 | — | — | 1 | - |
| CHEMBL343528 | — | — | 1 | - |
| CHEMBL436012 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341545 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL141228 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL344682 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL140029 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL345086 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL140875 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL337314 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL337540 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL138968 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL138058 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL344851 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL138313 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL138518 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL137926 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL341589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL138051 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL443220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139137 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL138160 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL343528 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL436012 | — | IC50 | > | 10000.0 | nM | - |