Assay Detail
Binding
CHEMBL816554
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Binding affinity towards trypsin was evaluated
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.43 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354555 | — | — | 1 | 5.82 |
| CHEMBL353431 | — | — | 1 | 5.68 |
| CHEMBL355441 | — | — | 1 | 5.52 |
| CHEMBL11157 | L-374087 | — | 1 | 5.50 |
| CHEMBL349430 | — | — | 1 | 5.37 |
| CHEMBL48929 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354555 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL353431 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL355441 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL11157 | L-374087 | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL349430 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL48929 | — | Ki | = | 20000.0 | nM | 4.70 |