Assay Detail
Binding
CHEMBL816558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of TNF-alpha converting enzyme.
21
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.88 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101864 | — | — | 1 | 7.58 |
| CHEMBL319887 | — | — | 1 | 7.58 |
| CHEMBL100134 | — | — | 1 | 7.44 |
| CHEMBL100777 | — | — | 1 | 7.31 |
| CHEMBL101210 | — | — | 1 | 7.20 |
| CHEMBL319902 | — | — | 1 | 7.06 |
| CHEMBL99745 | — | — | 1 | 6.97 |
| CHEMBL319341 | — | — | 1 | 6.91 |
| CHEMBL318922 | — | — | 1 | 6.84 |
| CHEMBL100512 | — | — | 1 | 6.81 |
| CHEMBL101413 | — | — | 1 | 6.80 |
| CHEMBL100280 | — | — | 1 | 6.76 |
| CHEMBL100564 | — | — | 1 | 6.70 |
| CHEMBL101981 | — | — | 1 | 6.68 |
| CHEMBL102057 | — | — | 1 | 6.68 |
| CHEMBL320383 | — | — | 1 | 6.66 |
| CHEMBL70176 | — | — | 3 | 6.64 |
| CHEMBL100950 | — | — | 1 | 6.61 |
| CHEMBL100081 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101864 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL319887 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL100134 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL100777 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL101210 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL319902 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL99745 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL319341 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL318922 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL100512 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL101413 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL100280 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL100564 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL101981 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL102057 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL320383 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL70176 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL100950 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL100081 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL70176 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL70176 | — | IC50 | = | 645.0 | nM | 6.19 |