Assay Detail
Functional
CHEMBL816613
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.90 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 9.50 |
| CHEMBL42407 | LANEPITANT | 2.0 | 1 | 9.40 |
| CHEMBL351274 | — | — | 1 | 9.00 |
| CHEMBL352102 | — | — | 1 | 6.30 |
| CHEMBL351236 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL42407 | LANEPITANT | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL351274 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL352102 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL351236 | — | Kd | = | 5011.87 | nM | 5.30 |