Assay Detail
Binding
CHEMBL816619
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Inhibition of Tachykinin receptor 1 of rat forebrain tissue
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Forebrain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and substance P antagonist activity of naphthimidazolium derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.50 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 9.92 |
| CHEMBL23096 | — | — | 1 | 6.75 |
| CHEMBL24818 | — | — | 1 | 6.51 |
| CHEMBL23360 | — | — | 1 | 6.51 |
| CHEMBL23287 | — | — | 1 | 6.50 |
| CHEMBL23147 | — | — | 1 | 6.44 |
| CHEMBL23682 | — | — | 1 | 6.41 |
| CHEMBL23073 | — | — | 1 | 6.39 |
| CHEMBL278135 | — | — | 1 | 6.35 |
| CHEMBL386306 | SPANTIDE | — | 1 | 6.30 |
| CHEMBL278294 | — | — | 1 | 6.29 |
| CHEMBL280339 | — | — | 1 | 6.10 |
| CHEMBL283990 | — | — | 1 | 5.89 |
| CHEMBL23181 | — | — | 1 | 5.70 |
| CHEMBL23533 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL23096 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL24818 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL23360 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL23287 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL23147 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL23682 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL23073 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL278135 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL386306 | SPANTIDE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL278294 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL280339 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL283990 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL23181 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL23533 | — | IC50 | = | 4200.0 | nM | 5.38 |