Assay Detail
Functional
CHEMBL816681
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.09 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305055 | — | — | 1 | 7.60 |
| CHEMBL66106 | — | — | 1 | 7.30 |
| CHEMBL66763 | — | — | 1 | 7.30 |
| CHEMBL308891 | — | — | 1 | 7.30 |
| CHEMBL446146 | — | — | 1 | 7.20 |
| CHEMBL67508 | — | — | 1 | 7.00 |
| CHEMBL303803 | — | — | 1 | 6.80 |
| CHEMBL540651 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305055 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL66106 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL66763 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL308891 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL446146 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL67508 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL303803 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL540651 | — | Kd | = | 630.96 | nM | 6.20 |