Assay Detail
Binding
CHEMBL816682
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Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
A new class of high affinity ligands for the neurokinin A NK2 receptor: psi (CH2NR) reduced peptide bond analogues of neurokinin A4-10.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.24 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339591 | — | — | 1 | 9.00 |
| CHEMBL217406 | NEUROKININ A | — | 1 | 9.00 |
| CHEMBL126294 | — | — | 1 | 8.22 |
| CHEMBL340743 | — | — | 1 | 8.05 |
| CHEMBL126776 | — | — | 1 | 8.00 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 7.75 |
| CHEMBL339615 | — | — | 1 | 7.30 |
| CHEMBL128854 | — | — | 1 | 6.99 |
| CHEMBL340880 | — | — | 1 | 6.97 |
| CHEMBL341015 | — | — | 1 | 6.94 |
| CHEMBL341065 | — | — | 1 | 6.87 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 6.83 |
| CHEMBL129301 | — | — | 1 | 6.79 |
| CHEMBL128521 | — | — | 1 | 6.71 |
| CHEMBL336849 | — | — | 1 | 6.56 |
| CHEMBL340847 | — | — | 1 | 5.78 |
| CHEMBL339941 | — | — | 1 | 5.25 |
| CHEMBL128175 | — | — | 1 | - |
| CHEMBL409334 | — | — | 1 | - |
| CHEMBL337970 | — | — | 1 | - |
| CHEMBL262731 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339591 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL217406 | NEUROKININ A | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL126294 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL340743 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL126776 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL437797 | NEUROKININ B | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL339615 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL128854 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL340880 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL341015 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL341065 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL235363 | SUBSTANCE P | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL129301 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL128521 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL336849 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL340847 | — | IC50 | = | 1652.0 | nM | 5.78 |
| CHEMBL339941 | — | IC50 | = | 5662.0 | nM | 5.25 |
| CHEMBL128175 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL409334 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL337970 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL262731 | — | IC50 | > | 10000.0 | nM | - |