Assay Detail
Binding
CHEMBL816688
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Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.15 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437797 | NEUROKININ B | — | 1 | 8.44 |
| CHEMBL45340 | — | — | 1 | 6.10 |
| CHEMBL47146 | — | — | 1 | 5.82 |
| CHEMBL296014 | — | — | 1 | 5.21 |
| CHEMBL444832 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437797 | NEUROKININ B | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL45340 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL47146 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL296014 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL444832 | — | IC50 | = | 6540.0 | nM | 5.18 |