Assay Detail
Binding
CHEMBL816795
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Inhibition of trypsin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.18 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332655 | — | — | 1 | 6.17 |
| CHEMBL121608 | — | — | 1 | 5.92 |
| CHEMBL434412 | — | — | 1 | 5.92 |
| CHEMBL114715 | INOGATRAN | 2.0 | 1 | 5.82 |
| CHEMBL421057 | — | — | 1 | 5.72 |
| CHEMBL332907 | — | — | 1 | 5.47 |
| CHEMBL121322 | — | — | 1 | 5.47 |
| CHEMBL118820 | — | — | 1 | 4.92 |
| CHEMBL333565 | — | — | 1 | 4.84 |
| CHEMBL333098 | — | — | 1 | 4.82 |
| CHEMBL339878 | — | — | 1 | 4.80 |
| CHEMBL120029 | — | — | 1 | 4.68 |
| CHEMBL120012 | — | — | 1 | 4.00 |
| CHEMBL421276 | — | — | 1 | 4.00 |
| CHEMBL331930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332655 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL121608 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL434412 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL114715 | INOGATRAN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL421057 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL332907 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL121322 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL118820 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL333565 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL333098 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL339878 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL120029 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL120012 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL421276 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL331930 | — | IC50 | = | 215000.0 | nM | - |