Assay Detail
Binding
CHEMBL816866
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Tested for in vitro inhibitory activity against tyrosine protein kinase pp60 c-src
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of tricyclic analogs related to ellagic acid as potent/selective tyrosine protein kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.65 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 6.52 |
| CHEMBL306019 | — | — | 1 | 6.40 |
| CHEMBL72338 | — | — | 1 | 6.40 |
| CHEMBL305223 | — | — | 1 | 6.40 |
| CHEMBL304361 | — | — | 1 | 6.30 |
| CHEMBL71144 | — | — | 1 | 6.30 |
| CHEMBL304362 | — | — | 1 | 6.22 |
| CHEMBL305621 | — | — | 1 | 6.22 |
| CHEMBL69174 | — | — | 1 | 6.22 |
| CHEMBL70346 | — | — | 1 | 6.22 |
| CHEMBL422771 | — | — | 1 | 6.16 |
| CHEMBL308112 | — | — | 1 | 6.16 |
| CHEMBL69240 | — | — | 1 | 6.10 |
| CHEMBL70594 | — | — | 1 | 6.05 |
| CHEMBL304808 | — | — | 1 | 6.05 |
| CHEMBL304983 | — | — | 1 | 6.05 |
| CHEMBL305234 | — | — | 1 | 6.05 |
| CHEMBL302483 | — | — | 1 | 6.05 |
| CHEMBL306785 | — | — | 1 | 6.00 |
| CHEMBL69237 | — | — | 1 | 5.89 |
| CHEMBL308175 | — | — | 1 | 5.85 |
| CHEMBL70659 | — | — | 1 | 5.82 |
| CHEMBL73937 | — | — | 1 | 5.77 |
| CHEMBL71002 | — | — | 1 | 5.70 |
| CHEMBL302472 | — | — | 1 | 5.70 |
| CHEMBL308438 | — | — | 1 | 5.70 |
| CHEMBL305966 | — | — | 1 | 5.47 |
| CHEMBL307112 | — | — | 1 | 5.40 |
| CHEMBL72682 | — | — | 1 | 5.39 |
| CHEMBL71210 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL306019 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL305223 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL72338 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL304361 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL71144 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL304362 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL305621 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL69174 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL70346 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL422771 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL308112 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL69240 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL302483 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL304808 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL304983 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL70594 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL305234 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL306785 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL69237 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL308175 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL70659 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL73937 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL302472 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL308438 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL71002 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL305966 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL307112 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL72682 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL71210 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL70750 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL302824 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL308311 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL266154 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL302981 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL72035 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL70413 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL302325 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL73721 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL421872 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL305794 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL70942 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL70360 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL71205 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL71206 | — | IC50 | = | 197000.0 | nM | - |