Assay Detail
Binding
CHEMBL816871
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Inhibition of human recombinant MMP14
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.75 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550148 | — | — | 1 | 7.16 |
| CHEMBL550081 | — | — | 1 | 6.50 |
| CHEMBL561625 | — | — | 1 | 6.28 |
| CHEMBL561038 | — | — | 1 | 6.23 |
| CHEMBL560837 | — | — | 1 | 6.00 |
| CHEMBL181244 | — | — | 1 | 5.64 |
| CHEMBL561039 | — | — | 1 | 5.62 |
| CHEMBL563679 | — | — | 1 | 5.55 |
| CHEMBL550350 | — | — | 1 | 5.47 |
| CHEMBL561036 | — | — | 1 | 5.26 |
| CHEMBL563026 | — | — | 1 | 5.19 |
| CHEMBL550628 | — | — | 1 | 4.96 |
| CHEMBL550548 | — | — | 1 | 4.85 |
| CHEMBL561630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550148 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL550081 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL561625 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL561038 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL560837 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL181244 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL561039 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL563679 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL550350 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL561036 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL563026 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL550628 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL550548 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL561630 | — | IC50 | > | 1000.0 | nM | - |