Assay Detail
Functional
CHEMBL816901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NADH-ubiquinone oxidoreductase using decylubiquinone (DB) acceptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.89 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159443 | — | — | 1 | 9.68 |
| CHEMBL351789 | — | — | 1 | 9.66 |
| CHEMBL160640 | LAHERRADURIN | — | 1 | 9.54 |
| CHEMBL609932 | — | — | 1 | 9.25 |
| CHEMBL161493 | — | — | 1 | 9.24 |
| CHEMBL349693 | — | — | 1 | 9.14 |
| CHEMBL142918 | rolliniastatin-1 | — | 1 | 9.13 |
| CHEMBL349802 | — | — | 1 | 8.92 |
| CHEMBL161030 | — | — | 1 | 8.85 |
| CHEMBL161529 | — | — | 1 | 8.54 |
| CHEMBL159586 | — | — | 1 | 8.48 |
| CHEMBL162504 | — | — | 1 | 8.33 |
| CHEMBL345841 | — | — | 1 | 8.29 |
| CHEMBL608197 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159443 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL351789 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL160640 | LAHERRADURIN | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL609932 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL161493 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL349693 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL142918 | rolliniastatin-1 | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL349802 | — | IC50 | = | 1.21 | nM | 8.92 |
| CHEMBL161030 | — | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL161529 | — | IC50 | = | 2.88 | nM | 8.54 |
| CHEMBL159586 | — | IC50 | = | 3.32 | nM | 8.48 |
| CHEMBL162504 | — | IC50 | = | 4.64 | nM | 8.33 |
| CHEMBL345841 | — | IC50 | = | 5.18 | nM | 8.29 |
| CHEMBL608197 | — | IC50 | = | 38.3 | nM | 7.42 |