Assay Detail
Binding
CHEMBL816912
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Displacement of [3H]vesamicol from Vesamicol receptor of Torpedo californica
14
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vesicular acetylcholine transporter (CHEMBL3313) ↗| Type | SINGLE PROTEIN |
| Organism | Torpedo californica |
Publication
Acyclic analogues of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.74 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89812 | — | — | 4 | 7.52 |
| CHEMBL20943 | — | — | 1 | 7.47 |
| CHEMBL314574 | — | — | 1 | 7.14 |
| CHEMBL84797 | — | — | 1 | 7.14 |
| CHEMBL90556 | — | — | 1 | 6.94 |
| CHEMBL88534 | — | — | 1 | 6.84 |
| CHEMBL89896 | — | — | 1 | 6.66 |
| CHEMBL88522 | — | — | 1 | 6.28 |
| CHEMBL89577 | — | — | 1 | 6.00 |
| CHEMBL314881 | — | — | 1 | 5.85 |
| CHEMBL87177 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89812 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL20943 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL89812 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL314574 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL84797 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL90556 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL88534 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL89812 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL89896 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL89812 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL88522 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL89577 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL314881 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL87177 | — | IC50 | = | 1540.0 | nM | 5.81 |