Assay Detail
Binding
CHEMBL816914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity to vesamicol receptor using [3H]vesamicol.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vesicular acetylcholine transporter (CHEMBL3313) ↗| Type | SINGLE PROTEIN |
| Organism | Torpedo californica |
Publication
Spirovesamicols: conformationally restricted analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, AH5183) as potential modulators of presynaptic cholinergic function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 9.16 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86366 | — | — | 1 | 10.30 |
| CHEMBL87379 | BENZOVESAMICOL | — | 1 | 10.26 |
| CHEMBL50880 | — | — | 1 | 10.20 |
| CHEMBL87595 | — | — | 1 | 9.92 |
| CHEMBL313710 | — | — | 1 | 9.83 |
| CHEMBL314848 | — | — | 1 | 9.67 |
| CHEMBL87693 | — | — | 1 | 9.61 |
| CHEMBL86983 | — | — | 1 | 9.58 |
| CHEMBL431223 | — | — | 1 | 9.57 |
| CHEMBL87414 | — | — | 1 | 9.44 |
| CHEMBL87594 | — | — | 1 | 9.44 |
| CHEMBL406130 | — | — | 1 | 9.39 |
| CHEMBL87232 | — | — | 1 | 9.20 |
| CHEMBL314170 | — | — | 1 | 9.18 |
| CHEMBL88046 | — | — | 1 | 9.12 |
| CHEMBL314687 | — | — | 1 | 9.10 |
| CHEMBL87214 | — | — | 1 | 9.10 |
| CHEMBL315226 | — | — | 1 | 9.07 |
| CHEMBL431413 | — | — | 1 | 9.01 |
| CHEMBL20730 | VESAMICOL | — | 1 | 9.00 |
| CHEMBL424241 | — | — | 1 | 8.85 |
| CHEMBL86816 | — | — | 1 | 8.58 |
| CHEMBL84738 | — | — | 1 | 8.24 |
| CHEMBL87287 | — | — | 1 | 8.16 |
| CHEMBL315146 | — | — | 1 | 8.12 |
| CHEMBL87435 | — | — | 1 | 7.74 |
| CHEMBL87652 | — | — | 1 | 7.62 |
| CHEMBL87381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86366 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL87379 | BENZOVESAMICOL | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL50880 | — | Ki | = | 0.063 | nM | 10.20 |
| CHEMBL87595 | — | Ki | = | 0.121 | nM | 9.92 |
| CHEMBL313710 | — | Ki | = | 0.147 | nM | 9.83 |
| CHEMBL314848 | — | Ki | = | 0.212 | nM | 9.67 |
| CHEMBL87693 | — | Ki | = | 0.248 | nM | 9.61 |
| CHEMBL86983 | — | Ki | = | 0.264 | nM | 9.58 |
| CHEMBL431223 | — | Ki | = | 0.271 | nM | 9.57 |
| CHEMBL87414 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL87594 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL406130 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL87232 | — | Ki | = | 0.638 | nM | 9.20 |
| CHEMBL314170 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL88046 | — | Ki | = | 0.762 | nM | 9.12 |
| CHEMBL314687 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL87214 | — | Ki | = | 0.798 | nM | 9.10 |
| CHEMBL315226 | — | Ki | = | 0.856 | nM | 9.07 |
| CHEMBL431413 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL20730 | VESAMICOL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL424241 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL86816 | — | Ki | = | 2.638 | nM | 8.58 |
| CHEMBL84738 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL87287 | — | Ki | = | 6.93 | nM | 8.16 |
| CHEMBL315146 | — | Ki | = | 7.59 | nM | 8.12 |
| CHEMBL87435 | — | Ki | = | 18.36 | nM | 7.74 |
| CHEMBL87652 | — | Ki | = | 24.25 | nM | 7.62 |
| CHEMBL87381 | — | Ki | = | 0.0065 | nM | - |