Assay Detail
Binding
CHEMBL816917
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Inhibition of MMP13-mediated collagen degradation by SDS-PAGE
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.28 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550548 | — | — | 1 | 8.85 |
| CHEMBL550148 | — | — | 1 | 8.62 |
| CHEMBL561625 | — | — | 1 | 8.03 |
| CHEMBL181244 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550548 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL550148 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL561625 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL181244 | — | IC50 | = | 25.0 | nM | 7.60 |