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Assay Detail

CHEMBL817004

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition constant against Urokinase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Urokinase-type plasminogen activator (CHEMBL3286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
Tidwell RR, Geratz JD, Dubovi EJ.
J Med Chem (1983) 26 : 294 -298
PubMed 6219223 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 4.83 5.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99951 1 5.63
CHEMBL103649 1 5.35
CHEMBL101672 1 5.10
CHEMBL101027 1 5.00
CHEMBL317713 1 4.97
CHEMBL101261 1 4.92
CHEMBL102148 1 4.75
CHEMBL102141 1 4.72
CHEMBL100569 1 4.59
CHEMBL101067 1 4.58
CHEMBL101726 1 4.44
CHEMBL101559 1 4.40
CHEMBL321960 1 4.39
CHEMBL102009 1 -
CHEMBL26490 1 -
CHEMBL100296 1 -
CHEMBL329730 1 -
CHEMBL101343 1 -
CHEMBL415700 1 -
CHEMBL101878 1 -
CHEMBL321524 1 -
CHEMBL322894 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99951 Ki = 2330.0 nM 5.63
CHEMBL103649 Ki = 4470.0 nM 5.35
CHEMBL101672 Ki = 8000.0 nM 5.10
CHEMBL101027 Ki = 9960.0 nM 5.00
CHEMBL317713 Ki = 10600.0 nM 4.97
CHEMBL101261 Ki = 12000.0 nM 4.92
CHEMBL102148 Ki = 17800.0 nM 4.75
CHEMBL102141 Ki = 19000.0 nM 4.72
CHEMBL100569 Ki = 25600.0 nM 4.59
CHEMBL101067 Ki = 26500.0 nM 4.58
CHEMBL101726 Ki = 36000.0 nM 4.44
CHEMBL101559 Ki = 40000.0 nM 4.40
CHEMBL321960 Ki = 40300.0 nM 4.39
CHEMBL102009 Ki = 267000.0 nM -
CHEMBL26490 Ki = 131000.0 nM -
CHEMBL100296 Ki > 200000.0 nM -
CHEMBL329730 Ki > 100000.0 nM -
CHEMBL101343 Ki = 191000.0 nM -
CHEMBL415700 Ki > 100000.0 nM -
CHEMBL101878 Ki = 196000.0 nM -
CHEMBL321524 Ki > 100000.0 nM -
CHEMBL322894 Ki = 280000.0 nM -