Assay Detail
Binding
CHEMBL817007
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Inhibitory activity against UK.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.44 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107627 | — | — | 1 | 4.55 |
| CHEMBL107392 | — | — | 1 | 4.55 |
| CHEMBL322901 | — | — | 1 | 4.50 |
| CHEMBL322165 | — | — | 1 | 4.47 |
| CHEMBL319035 | — | — | 1 | 4.31 |
| CHEMBL107743 | — | — | 1 | 4.24 |
| CHEMBL107282 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107627 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL107392 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL322901 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL322165 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL319035 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL107743 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL107282 | — | Ki | = | 140000.0 | nM | - |