Assay Detail
Functional
CHEMBL817042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against resistant cell line of WiDr human colon tumor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.18 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.82 |
| CHEMBL146101 | — | — | 1 | 7.75 |
| CHEMBL146104 | — | — | 1 | 7.30 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290677 | AZONAFIDE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL146101 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL146104 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 1400.0 | nM | 5.85 |