Assay Detail
Binding
CHEMBL817082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidney
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of novel vasopressin antagonists containing C-terminal diaminoalkanes and (aminoalkyl)guanidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.36 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416114 | — | — | 1 | 8.48 |
| CHEMBL2370646 | — | — | 1 | 8.44 |
| CHEMBL265591 | — | — | 1 | 8.43 |
| CHEMBL2370640 | — | — | 1 | 8.38 |
| CHEMBL2370642 | — | — | 1 | 8.32 |
| CHEMBL2370641 | — | — | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416114 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL2370646 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL265591 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL2370640 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL2370642 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL2370641 | — | Ki | = | 7.6 | nM | 8.12 |